Structural and mechanistic insights into enantioselectivity toward near-symmetric esters of a novel carboxylesterase RoCE

Abstract

A novel carboxylesterase RoCE was identified with relatively high enantioselectivity toward “hard-to-be-discriminated” oxyheterocyclic esters. Molecular basis of enantioselectivity was elucidated and applied in increasing enantioselectivity of RoCE.