Synthesis, Isolation, and Analysis of Stereoisomers of Sacubitril

Author:

Halama Aleš1ORCID,Zapadlo Michal1

Affiliation:

1. Department of Chemical Synthesis, Zentiva k.s., U kabelovny 130, Prague 102 01, Czech Republic

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference8 articles.

1. Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

2. US Food and Drug Administration. https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DrugInnovation/ucm474696.htm. Novel Drugs Summary 2015.

3. Dicarboxylic Acid Dipeptide Neutral Endopeptidase Inhibitors

4. Hook, D.; Wietfeld, B.; Lotz, M. Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors. WO2008031567 A1, 2008.

5. Diastereoselective Synthesis of an Industrially Relevant 4-Aminopentanoic Acid by Asymmetric Catalytic Hydrogenation in a Biphasic­ System Using Aqueous Sodium Hydroxide as Substrate Phase

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