Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes-Reference-Cited by-同舟云学术

Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes

Published:2018 Issue:10 Volume:9 Page:2733-2739
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wootton Christopher A.¹²³⁴^ORCID,Sanchez-Cano Carlos¹²³⁴^ORCID,Lopez-Clavijo Andrea F.¹²³⁴^ORCID,Shaili Evyenia¹²³⁴^ORCID,Barrow Mark P.¹²³⁴^ORCID,Sadler Peter J.¹²³⁴^ORCID,O'Connor Peter B.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Warwick

3. Coventry CV4 7AL

4. UK

Abstract

Octahedral anticancer platinum(iv) complexes such as trans,trans,trans-[Pt(N₃)₂(OH)₂(pyridine)₂] (1) can target peptides (and proteins) by sequence-dependent platination and radical mechanisms when activated by UVA or visible light; the specific products are highly dependent on their amino acid composition of the peptide.

Funder

Engineering and Physical Sciences Research Council

FP7 Ideas: European Research Council

Warwick University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC05135B

Reference58 articles.

1. Interactions of DNA with a New Platinum(IV) Azide Dipyridine Complex Activated by UVA and Visible Light: Relationship to Toxicity in Tumor Cells