Modular and hierarchical self-assembly of siRNAs into supramolecular nanomaterials for soft and homogeneous siRNA loading and precise and visualized intracellular delivery-Reference-Cited by-同舟云学术

Modular and hierarchical self-assembly of siRNAs into supramolecular nanomaterials for soft and homogeneous siRNA loading and precise and visualized intracellular delivery

Published:2022 Issue:29 Volume:13 Page:8657-8666
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Guan Xiaowen¹,Meng Fanqi¹,Tan Hongwei¹,Wang Xiaoni¹,Li Jingjing¹,Wei Juanjuan¹,Ouyang Jin¹^ORCID,Na Na¹^ORCID

Affiliation:

1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China

Abstract

Supramolecular nanomaterials of WP5⊃G–siRNA were constructed by modular and hierarchical self-assembly of siRNA with guest and host molecules, initiating weak acidic-responsive, precise and visualized intracellular delivery for efficient therapies.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC02488H

Reference49 articles.

1. RNAi

2. From biology to materials: engineering DNA and RNA for drug delivery and nanomedicine