Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin-Reference-Cited by-同舟云学术

Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin

Published:2021 Issue:32 Volume:12 Page:10893-10900
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hu Xuqiao¹,Li Hongyan¹,Ip Tiffany Ka-Yan¹,Cheung Yam Fung¹,Koohi-Moghadam Mohamad¹²,Wang Haibo¹,Yang Xinming¹,Tritton Daniel N.¹,Wang Yuchuan¹,Wang Yi¹^ORCID,Wang Runming¹,Ng Kwan-Ming¹³^ORCID,Naranmandura Hua⁴^ORCID,Tse Eric Wai-Choi⁵^ORCID,Sun Hongzhe¹^ORCID

Affiliation:

1. Department of Chemistry and CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Hong Kong SAR, P. R. China

2. Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, University of Hong Kong, Hong Kong SAR, P. R. China

3. Department of Chemistry, Shantou University, Shantou, Guangdong, 515063, P. R. China

4. Department of Toxicology, School of Medicine and Public Health, Zhejiang University, Hangzhou, P.R. China

5. Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, P. R. China

Abstract

A highly selective organoarsenic fluorescent probe As-AC and quantitative proteomics were employed to track arsenic-binding and regulating proteins in live leukemia cells. Hsp60 was validated as a new target of ATO.

Funder

Research Grants Council, University Grants Committee

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC03119H

Reference52 articles.

1. H.Sun , in Biological Chemistry of Arsenic, Antimony and Bismuth , John Wiley & Sons, Ltd , Chiester , 2010

2. Arsenic trioxide-based therapy of relapsed acute promyelocytic leukemia: registry results from the European LeukemiaNet

3. Arsenic compounds: revived ancient remedies in the fight against human malignancies