The “Doorstop Pocket” In Thioredoxin Reductases─An Unexpected Druggable Regulator of the Catalytic Machinery-Reference-Cited by-同舟云学术

The “Doorstop Pocket” In Thioredoxin Reductases─An Unexpected Druggable Regulator of the Catalytic Machinery

Published:2024-09-09 Issue: Volume: Page:
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ardini Matteo¹,Aboagye Sammy Y.²,Petukhova Valentina Z.³,Kastrati Irida⁴,Ippoliti Rodolfo¹,Thatcher Gregory R. J.⁵^ORCID,Petukhov Pavel A.³^ORCID,Williams David L.²^ORCID,Angelucci Francesco¹^ORCID

Affiliation:

1. Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy

2. Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois 60612, United States

3. Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States

4. Department of Cancer Biology, Loyola University Chicago, 60153 Maywood, Illinois 60153, United States

5. Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, University of Arizona, Tucson, Arizona 85721, United States

Funder

European Commission

Division of Microbiology and Infectious Diseases

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00669

Reference155 articles.

1. The diversity and evolution of thioredoxin reductase: new perspectives

2. Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases

3. Thioredoxin Reductase Inhibition for Cancer Therapy

4. Thioredoxin Glutathione Reductase-Dependent Redox Networks in Platyhelminth Parasites

5. Targeting the Thioredoxin System for Cancer Therapy