Metal-free synthesis of <i>gem</i>-difluorinated heterocycles from enaminones and difluorocarbene precursors-Reference-Cited by-同舟云学术

Metal-free synthesis of gem-difluorinated heterocycles from enaminones and difluorocarbene precursors

Published:2022 Issue:21 Volume:58 Page:3477-3480
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wang Fei¹^ORCID,Fu Rui¹,Chen Jie¹²,Rong Jiaxin¹,Wang Enfu²,Zhang Jian²,Zhang Zhengyu¹,Jiang Yaojia¹²^ORCID

Affiliation:

1. Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing, 211816, China

2. Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education, Guizhou University, Huaxi District, Guiyang, 550025, China

Abstract

A cascade strategy to synthesise gem-difluorinated 2H-furans from reactions of BrCF2CO2Et with enaminones has been described. The reactions work efficiently for a broad substrate scope and tolerate a variety of functional groups under very mild metal-free conditions.

Funder

National Natural Science Foundation of China

Guizhou University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC00383J

Reference67 articles.

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