Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams

Author:

Piens Nicola12345,De Craene Sven12345,Franceus Jorick63457,Mollet Karen12345,Van Hecke Kristof891045,Desmet Tom63457,D'hooghe Matthias12345

Affiliation:

1. SynBioC Research Group

2. Department of Sustainable Organic Chemistry and Technology

3. Faculty of Bioscience Engineering

4. Ghent University

5. B-9000 Ghent

6. Department of Biochemical and Microbial Technology

7. Belgium

8. XStruct

9. Department of Inorganic and Physical Chemistry

10. Faculty of Sciences

Abstract

Synthesis of 3,4-oxolane-fused bicyclic β-lactams as anchor compounds for further β-lactamase inhibitor development.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference69 articles.

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4. The antibiotics market

5. S. A. Testero , J. F.Fisher and S.Mobashery, in Burger's Medicinal Chemistry, Drug Discovery and Development, ed. D. J. Abraham and D. P. Rotella, John Wiley & Sons, 2010, vol. 7, p. 257

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