Design of pyrazolo-pyrimidines as 11β-HSD1 inhibitors through optimisation of molecular electrostatic potential-Reference-Cited by-同舟云学术

Design of pyrazolo-pyrimidines as 11β-HSD1 inhibitors through optimisation of molecular electrostatic potential

Published:2015 Issue:5 Volume:6 Page:926-934
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Robb Graeme R.¹²,Boyd Scott¹²,Davies Christopher D.¹²,Dossetter Alexander G.¹²,Goldberg Frederick W.¹²,Kemmitt Paul D.¹²,Scott James S.¹²,Swales John G.¹²

Affiliation:

1. AstraZeneca

2. United Kingdom

Abstract

Rapid and efficient lead optimisation through quantification of the molecular electrostatic potential using quantum mechanics.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00043B

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