Fluorine teams up with water to restore inhibitor activity to mutant BPTI-Reference-Cited by-同舟云学术

Fluorine teams up with water to restore inhibitor activity to mutant BPTI

Published:2015 Issue:9 Volume:6 Page:5246-5254
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ye Shijie¹²³⁴⁵,Loll Bernhard¹²⁶⁴⁵^ORCID,Berger Allison Ann¹²³⁴⁵,Mülow Ulrike¹²³⁴⁵,Alings Claudia¹²⁶⁴⁵,Wahl Markus Christian¹²⁶⁴⁵,Koksch Beate¹²³⁴⁵

Affiliation:

1. Department of Biology, Chemistry, and Pharmacy

2. Freie Universität Berlin

3. Institute of Chemistry and Biochemistry

4. Berlin, 14195

5. Germany

6. Institute of Chemistry and Biochemistry, Structural Biochemistry

Abstract

Fluorinated derivatives of aminobutyric acid engage in unique interactions with structural waters within the BPTI/trypsin interface and restore inhibitor activity.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C4SC03227F

Reference50 articles.

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4. NMR Methods for the Determination of Protein- Ligand Dissociation Constants

5. Current applications of 19F NMR to studies of protein structure and dynamics

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