Identification of novel 1,2,3-triazole isatin derivatives as potent SARS-CoV-2 3CLpro inhibitors <i>via</i> click-chemistry-based rapid screening-Reference-Cited by-同舟云学术

Identification of novel 1,2,3-triazole isatin derivatives as potent SARS-CoV-2 3CLpro inhibitors via click-chemistry-based rapid screening

Published:2023 Issue:10 Volume:14 Page:2068-2078
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Jiang Xiangyi¹^ORCID,Li Jing¹,Viayna Antonio²³^ORCID,Luque F. Javier²³⁴^ORCID,Woodson Molly⁵⁶,Jing Lanlan¹,Gao Shenghua¹,Zhao Fabao¹,Xie Minghui¹,Toth Karoly⁵⁶,Tavis John⁵⁶,Tollefson Ann E.⁵⁶,Liu Xinyong¹^ORCID,Zhan Peng¹

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, PR China

2. Departament de Nutrició, Ciències de l'Alimentació i Gastronomia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona (UB), Av. Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain

3. Institut de Biomedicina (IBUB), Universitat de Barcelona (UB), Barcelona, Spain

4. Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona (UB), Barcelona, Spain

5. Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA

6. Saint Louis University Institute for Drug and Biotherapeutic Innovation, St. Louis, Missouri 63104, USA

Abstract

SARS-CoV-2 3-chymotrypsin-like protease (3CLpro) is considered an attractive target for the development of anti-COVID-19 agents due to its vital function.

Funder

Shandong Provincial Natural Science Foundation

Basic and Applied Basic Research Foundation of Guangdong Province

Ministerio de Ciencia e Innovación

China Postdoctoral Science Foundation

Generalitat de Catalunya

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00306J