Discovery of 3-oxo-1,2,3,4-tetrahydropyrido[1,2-a]pyrazin derivatives as SARS-CoV-2 main protease inhibitors through virtual screening and biological evaluation

Author:

Dou XiaodongORCID,Sun QiORCID,Liu Yameng,Lu Yangbin,Zhang Caifang,Xu Guofeng,Xu Yue,Huo Tongyu,Zhao Xinyi,Su Lingyu,Xing Yihong,Lai Luhua,Jiao NingORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference43 articles.

1. A novel coronavirus from patients with pneumonia in China, 2019;Zhu;N Engl J Med,2020

2. Importation and human-to-human transmission of a novel coronavirus in Vietnam;Phan;N Engl J Med,2020

3. A novel coronavirus outbreak of global health concern;Wang;Lancet,2020

4. World Health Organization (WHO). WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int/.

5. Therapeutic options for the 2019 novel coronavirus (2019-nCoV);Li;Nat Rev Drug Discov,2020

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