Rational design, synthesis, molecular modeling, biological activity, and mechanism of action of polypharmacological norfloxacin hydroxamic acid derivatives-Reference-Cited by-同舟云学术

Rational design, synthesis, molecular modeling, biological activity, and mechanism of action of polypharmacological norfloxacin hydroxamic acid derivatives

Published:2023 Issue:12 Volume:14 Page:2593-2610
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Kamal El-sagheir Ahmed M.¹,Abdelmesseh Nekhala Ireny²,Abd El-Gaber Mohammed K.¹,Aboraia Ahmed S.¹^ORCID,Persson Jonatan²³,Schäfer Ann-Britt²³,Wenzel Michaela²³^ORCID,Omar Farghaly A.¹^ORCID

Affiliation:

1. Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt

2. Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, 412 96 Gothenburg, Sweden

3. Center for Antibiotic Resistance Research in Gothenburg (CARe), Gothenburg, Sweden

Abstract

Addition of metal-chelating and lipophilic groups to norfloxacin yielded dual-action compounds inhibiting DNA gyrase/topoisomerase IV and bacterial cell wall synthesis.

Funder

Chalmers Tekniska Högskola

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00309D

Reference58 articles.

1. Fighting infections due to multidrug-resistant Gram-positive pathogens

2. Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It

3. Progress in the Prevalence, Classification and Drug Resistance Mechanisms of Methicillin-Resistant Staphylococcus aureus

4. Pan Drug-Resistant Environmental Isolate of Acinetobacter baumannii from Croatia

5. Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era?

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