Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles-Reference-Cited by-同舟云学术

Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles

Published:2024-04-20 Issue:9 Volume:67 Page:7406-7430
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hefny Salma M.¹^ORCID,El-Moselhy Tarek F.¹,El-Din Nabaweya¹,Giovannuzzi Simone²,Bin Traiki Thamer³,Vaali-Mohammed Mansoor-Ali³,El-Dessouki Ahmed M.⁴,Yamaguchi Koki⁵,Sugiura Masaharu⁵^ORCID,Shaldam Moataz A.⁶^ORCID,Supuran Claudiu T.²^ORCID,Abdulla Maha-Hamadien³,Eldehna Wagdy M.⁶^ORCID,Tawfik Haytham O.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt

2. Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze Italy

3. Department of Surgery, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia

4. Pharmacology and Toxicology Department, Faculty of Pharmacy, Ahram Canadian University, sixth of October City, Giza 12566, Egypt

5. Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan

6. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

Funder

King Saud University

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00239

Reference100 articles.

1. The solid tumor microenvironment—Breaking the barrier for T cells

2. Promising applications of nanotechnology in inhibiting chemo-resistance in solid tumors by targeting epithelial-mesenchymal transition (EMT)

3. Interplay of Carbonic Anhydrase IX With Amino Acid and Acid/Base Transporters in the Hypoxic Tumor Microenvironment

4. Oxygen availability and metabolic reprogramming in cancer

5. Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

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