A TCF-based fluorescent probe to determine nitroreductase (NTR) activity for a broad-spectrum of bacterial species

Author:

Yan Kai-Cheng12ORCID,Gardiner Jordan E.1ORCID,Sedgwick Adam C.3ORCID,Thet Naing1ORCID,Heylen Rachel A.1ORCID,James Tony D.14ORCID,Jenkins A. Toby A.1ORCID,He Xiao-Peng25ORCID

Affiliation:

1. Department of Chemistry, University of Bath, Bath, BA2 7AY, UK

2. Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, China

3. Chemistry Research Laboratory, University of Oxford, Mansfield Road, OX1 3TA, UK

4. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China

5. National Center for Liver Cancer, The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200433, P. R. China

Abstract

A nitroreductase (NTR) responsive fluorescent probe with long wavelength fluorescence emission was used to determine the NTR activity of a selection of bacterial species under a range of different bacterial growth conditions.

Funder

Engineering and Physical Sciences Research Council

National Natural Science Foundation of China

East China University of Science and Technology

Fundamental Research Funds for the Central Universities

Project 211

Henan Normal University

University of Oxford

Jesus College, University of Oxford

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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