Design, synthesis, crystal structure and anti-plasmodial evaluation of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives-Reference-Cited by-同舟云学术

Design, synthesis, crystal structure and anti-plasmodial evaluation of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives

Published:2021 Issue:6 Volume:12 Page:970-981
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Pal Kavita¹²³⁴⁵,Raza Md Kausar⁶⁷⁸⁵,Legac Jenny⁹¹⁰¹¹¹²,Ataur Rahman Md.¹³¹⁴¹⁵¹²,Manzoor Shoaib¹²³⁴⁵,Rosenthal Philip J.⁹¹⁰¹¹¹²,Hoda Nasimul¹²³⁴⁵^ORCID

Affiliation:

1. Drug Design and Synthesis Laboratory

2. Department of chemistry

3. Jamia Millia Islamia

4. New Delhi 110025

5. India

6. Department of Inorganic and Physical Chemistry

7. Indian Institute of Science

8. Bangalore 560012

9. Department of Medicine

10. University of California

11. San Francisco

12. USA

13. Department of Chemistry and Chemical Biology

14. Harvard University

15. Cambridge

Abstract

This work reports the design and synthesis of a library of thieno[2,3-d]pyrimidine derivatives and screened for their in vitro anti-plasmodial and cytotoxic assessment to identify a lead compound in the development of potential antimalarials.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00038A

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