The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis-Reference-Cited by-同舟云学术

The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis

Published:2019 Issue:1 Volume:10 Page:118-133
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Schoppet Melanie¹²³⁴⁵,Peschke Madeleine⁶⁷⁸,Kirchberg Anja¹²³⁴⁵,Wiebach Vincent⁹¹⁰¹¹⁸,Süssmuth Roderich D.⁹¹⁰¹¹⁸,Stegmann Evi¹²¹³¹⁴⁸¹⁵,Cryle Max J.¹²³⁴⁵^ORCID

Affiliation:

1. The Monash Biomedicine Discovery Institute

2. Department of Biochemistry and Molecular Biology

3. EMBL Australia

4. Monash University

5. Clayton

6. Department of Biomolecular Mechanisms

7. Max Planck Institute for Medical Research

8. Germany

9. Institut für Chemie

10. Technische Universität Berlin

11. 10623 Berlin

12. Interfaculty Institute of Microbiology and Infection Medicine Tübingen

13. Microbiology/Biotechnology

14. University of Tübingen

15. German Centre for Infection Research (DZIF)

Abstract

The condensation domain synthesising the last peptide bond in glycopeptide antibiotic biosynthesis has a preference for linear peptide substrates, with effective peptide formation linked to the rate of amino acid activation by the preceding adenylation domain.

Funder

National Health and Medical Research Council

Deutsche Forschungsgemeinschaft

Deutscher Akademischer Austauschdienst

Australian Research Council

Monash University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC03530J