Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies

Author:

Bouquerel Charlotte123ORCID,Dubrova Anastasiia1,Hofer Isabella2,Phan Duc T. T.4,Bernheim Moencopi1,Ladaigue Ségolène2,Cavaniol Charles1ORCID,Maddalo Danilo5ORCID,Cabel Luc6,Mechta-Grigoriou Fatima2,Wilhelm Claire1,Zalcman Gérard27,Parrini Maria Carla2,Descroix Stéphanie1ORCID

Affiliation:

1. Macromolécules et Microsystèmes en Biologie et Médecine, UMR 168, Institut Curie, Institut Pierre Gilles de Gennes, 6 rue Jean Calvin, 75005, Paris, France

2. Stress and Cancer Laboratory, Inserm, U830, Institut Curie, PSL Research University, 26 rue d'Ulm, 75005, Paris, France

3. Fluigent, 67 avenue de Fontainebleau, 94270, Le Kremlin-Bicêtre, France

4. Biomedicine Design, Pfizer Inc., San Diego, CA, USA

5. Department of Translational Oncology, Genentech, Inc., South San Francisco, CA 94080, USA

6. Institut Curie, Department of Medical Oncology, 26 rue d'Ulm, 75005, Paris, France

7. Université Paris Cité, Thoracic Oncology Department, INSERM CIC1425, Bichat Hospital, Cancer Institute AP-HP. Nord, Paris, France

Abstract

We present a multidisciplinary perspective by bringing together physicists, biologists, clinicians, and experts from pharmaceutical companies. We conducted an extensive systematic analysis of publications related to tumor-on-chip.

Funder

Centre National de la Recherche Scientifique

Association Nationale de la Recherche et de la Technologie

Institut Pierre-Gilles de Gennes

Fondation ARC pour la Recherche sur le Cancer

Institut National de la Santé et de la Recherche Médicale

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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