Estimation of clinical trial success rates and related parameters

Author:

Wong Chi Heem1,Siah Kien Wei1,Lo Andrew W2

Affiliation:

1. MIT Computer Science and Artificial Intelligence Laboratory & Department of Electrical Engineering and Computer Science, Cambridge, MA 02139, USA and MIT Sloan School of Management and Laboratory for Financial Engineering, Cambridge, MA 02142, USA

2. MIT Computer Science and Artificial Intelligence Laboratory & Department of Electrical Engineering and Computer Science, Cambridge, MA 02139, USA, MIT Sloan School of Management and Laboratory for Financial Engineering, Cambridge, MA 02142, USA, and AlphaSimplex Group, LLC, Cambridge, MA 02142, USA

Funder

MIT Laboratory for Financial Engineering

Publisher

Oxford University Press (OUP)

Subject

Statistics, Probability and Uncertainty,General Medicine,Statistics and Probability

Reference10 articles.

1. Pharmaceutical development phases: a duration analysis.;Abrantes-Metz;Journal of Pharmaceutical Finance, Economics and Policy,2005

2. Productivity in pharmaceutical–biotechnology R&D: the role of experience and alliances.;Danzon;Journal of Health Economics,2005

3. Trends in risks associated with new drug development: success rates for investigational drugs.;DiMasi;Clinical Pharmacology and Therapeutics,2010

4. Clinical development success rates for investigational drugs.;Hay;Nature Biotechnology,2014

5. Nonparametric kernel density estimation near the boundary.;Malec;Computational Statistics & Data Analysis,2014

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