Cobalt-promoted synthesis of sulfurated oxindoles <i>via</i> radical annulation of <i>N</i>-arylacrylamides with disulfides-Reference-Cited by-同舟云学术

Cobalt-promoted synthesis of sulfurated oxindoles via radical annulation of N-arylacrylamides with disulfides

Published:2022 Issue:32 Volume:20 Page:6423-6431
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cheng Fei¹,Bai Xue²,Sun Qi-Wen¹,Zhu Gao-Feng¹,Dong Yong-Xi¹,Yang Yuan-Yong¹^ORCID,Gao Xiu-Li¹,Guo Bing³,Tang Lei¹,Zhang Ji-Quan¹^ORCID

Affiliation:

1. Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, College of Pharmacy, Guizhou Medical University, Guiyang, 550025, China

2. Pharmacy Department of Guizhou Provincial People's Hospital, Guiyang 550002, China

3. Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, China

Abstract

An efficient radical synthesis of sulfurated oxindoles is developed using CoBr2 as both an initiator and a promoter. By controlling the CoBr2/(NH4)2S2O8 ratio, a wide range of sulfurated and brominated/sulfurated oxindoles are selectively prepared.

Funder

Natural Science Foundation of Guizhou Province

Key Laboratory of Microbial Resources and Drug Development in Guizhou Province

Guizhou Medical University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00877G

Reference61 articles.