Highly stable triple helix formation by homopyrimidine (l)-acyclic threoninol nucleic acids with single stranded DNA and RNA-Reference-Cited by-同舟云学术

Highly stable triple helix formation by homopyrimidine (l)-acyclic threoninol nucleic acids with single stranded DNA and RNA

Published:2015 Issue:8 Volume:13 Page:2366-2374
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kumar Vipin¹²³⁴⁵,Kesavan Venkitasamy¹²³⁴⁵,Gothelf Kurt V.⁶⁷⁸⁹¹⁰

Affiliation:

1. Chemical Biology Laboratory

2. Department of Biotechnology

3. Indian Institute of Technology

4. Madras (IITM)

5. Chennai 600036

6. Danish National Research Foundation Center for DNA Nanotechnology

7. iNANO and Department of Chemistry

8. Aarhus University

9. 8000 Aarhus C

10. Denmark

Abstract

Homopyrimidine acyclic (l)-threoninol nucleic acid (aTNA) was synthesized and found to form highly stable (l)-aTNA–DNA–(l)-aTNA and (l)-aTNA–RNA–(l)-aTNA triple helical structures.

Funder

Danish National Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02328E

Reference28 articles.

1. Amino acid nucleic acids: synthesis and hybridization properties of a novel class of antisense oligonucleotides

2. Synthesis and Hybridization Properties of Sugar-Modified Oligonucleotides

3. A Simple Glycol Nucleic Acid

4. N2′→P3′ Phosphoramidate Glycerol Nucleic Acid as a Potential Alternative Genetic System

5. Unexpectedly Stable Artificial Duplex from Flexible Acyclic Threoninol

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