Reversible PEGylation and Schiff-base linked imidazole modification of polylysine for high-performance gene delivery-Reference-Cited by-同舟云学术

Reversible PEGylation and Schiff-base linked imidazole modification of polylysine for high-performance gene delivery

Published:2015 Issue:8 Volume:3 Page:1507-1517
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Cai Xiaojun¹²³⁴⁵,Li Yongyong⁵⁶⁷⁸⁴,Yue Dong¹²³⁴,Yi Qiangying¹²³⁴,Li Shuo¹²³⁴⁹,Shi Donglu⁵⁶⁷⁸⁴,Gu Zhongwu¹²³⁴

Affiliation:

1. National Engineering Research Center for Biomaterials

2. Sichuan University

3. Chengdu 610064

4. China

5. The Institute for Biomedical Engineering and Nano Science

6. Tongji University School of Medicine

7. Tongji University

8. Shanghai

9. School of Chemical Engineering

Abstract

In the designed polylysine based catiomer the reversible PEGylation was introduced forin vivocirculation and to augment the cellular internalization, while the Schiff-base linked imidazole to accelerate the endosomal escape and facilitate intracellular DNA unpacking and release.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2015/TB/C4TB01724B

Reference62 articles.

1. Efficient Gene Delivery Vectors by Tuning the Surface Charge Density of Amino Acid-Functionalized Gold Nanoparticles

2. Polyphosphonium Polymers for siRNA Delivery: An Efficient and Nontoxic Alternative to Polyammonium Carriers

3. Intracellular Microenvironment Responsive Polymers: A Multiple-stage Transport Platform for High-Performance Gene Delivery

4. UV light-triggered unpacking of DNA to enhance gene transfection of azobenzene-containing polycations

5. Dual-targeted polyplexes: One step towards a synthetic virus for cancer gene therapy

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