Cytotoxic RuII-p-cymene complexes of an anthraimidazoledione: halide dependent solution stability, reactivity and resistance to hypoxia deactivation-Reference-Cited by-同舟云学术

Cytotoxic RuII-p-cymene complexes of an anthraimidazoledione: halide dependent solution stability, reactivity and resistance to hypoxia deactivation

Published:2019 Issue:21 Volume:48 Page:7187-7197
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Sarkar Amrita¹²³,Acharya Sourav¹²³,Khushvant Kumar¹²³,Purkait Kallol¹²³,Mukherjee Arindam¹²³^ORCID

Affiliation:

1. Department of Chemical Sciences

2. Indian Institute of Science Education and Research Kolkata

3. India

Abstract

Iodo coordinated half-sandwich Ru^II-anthraimidazoldione shows stability and low cytotoxicity even under hypoxia in metastatic cancer MDA-MB-231 cells (1–2 μM), induces apoptosis without ROS, and prevents migration at IC₂₀ dose.

Funder

Science and Engineering Research Board

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/DT/C8DT04687E

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