Reproducibility in the unfolding process of protein induced by an external electric field

Author:

Sinelnikova Anna1234,Mandl Thomas12345,Östlin Christofer1234ORCID,Grånäs Oscar1234ORCID,Brodmerkel Maxim N.6274ORCID,Marklund Erik G.6274ORCID,Caleman Carl12348ORCID

Affiliation:

1. Department of Physics and Astronomy

2. Uppsala University

3. SE-751 20 Uppsala

4. Sweden

5. University of Applied Sciences Technikum Wien

6. Department of Chemistry – BMC

7. SE-751 23 Uppsala

8. Center for Free-Electron Laser Science

Abstract

Controlled unfolding of proteins can reveal structural properties and give insights of the proteins' dynamics. We show the feasibility of unfolding proteins in the gas phase using electric fields, with a well-defined path at high field strengths.

Funder

H2020 Future and Emerging Technologies

Royal Swedish Academy of Sciences

Deutsches Elektronen-Synchrotron

Knut och Alice Wallenbergs Stiftelse

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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