Synthesis, characterization and in vitro cytotoxicity of gold(iii) dialkyl/diaryldithiocarbamato complexes

Author:

Altaf Muhammad1234,Isab Anvarhusein A.5234,Vančo Ján678910,Dvořák Zdeněk678910,Trávníček Zdeněk678910,Stoeckli-Evans Helen11121314

Affiliation:

1. Centre of Research Excellence in Nanotechnology (CENT)

2. King Fahd University of Petroleum and Minerals

3. Dhahran 31261

4. Saudi Arabia

5. Department of Chemistry

6. Regional Centre of Advanced Technologies and Materials

7. Division of Biologically Active Complexes and Molecular Magnets

8. Faculty of Science

9. Palacký University

10. CZ-771 46 Olomouc

11. Institute of Physics

12. University of Neuchâtel

13. CH-2000 Neuchâtel

14. Switzerland

Abstract

A series of six dialkyl/diaryldithiocarbamato (dtc) gold(iii) complexes [Au(R2dtc)2]Cl (1,3, and5), and [Au(R2dtc)Cl2] (2,4, and6), (R = methyl, ethyl, and benzyl) was synthesised and evaluated for anticancer activity with promising results (EC50≈ 9.5 μM).

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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