Liposomal formulation of a gold(iii) metalloantibiotic: a promising strategy against antimicrobial resistance

Author:

Llamedo Alejandro12,Rodríguez Pablo1,Gabasa Yaiza34,Soengas Raquel G.2ORCID,Rodríguez-Solla Humberto2ORCID,Elorriaga David2ORCID,García-Alonso Francisco J.2,Soto Sara M.34

Affiliation:

1. Nanovex Biotechnologies S.L., Parque Tecnológico de Asturias Edificio CEEI, 33428 Llanera, Spain

2. Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo, Julián Clavería 8, 33006 Oviedo, Spain

3. ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain

4. CIBER Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

Abstract

A novel gold(iii) metalloantibiotic liposomal formulation was developed. The nanoformulation show high stability and suitable properties for drug delivery, representing a promising strategy to fight against drug-resistant bacteria.

Funder

Instituto de Salud Carlos III

Ministerio de Economía y Competitividad

Publisher

Royal Society of Chemistry (RSC)

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