Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase-Reference-Cited by-同舟云学术

Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

Published:2014 Issue:46 Volume:50 Page:6098-6100
ISSN:1359-7345
Container-title:Chem. Commun.
language:en
Short-container-title:Chem. Commun.

Author:

Richter Nina¹²³⁴⁵,Simon Robert C.¹⁶⁷,Kroutil Wolfgang⁴⁵⁶⁷¹,Ward John M.⁸²³,Hailes Helen C.¹²³

Affiliation:

1. Department of Chemistry

2. University College London

3. London, UK

4. ACIB GmbH

5. c/o Department of Chemistry

6. University of Graz

7. 8010 Graz, Austria

8. Department of Biochemical Engineering

Abstract

An efficient and stereoselective biocatalytic route for the synthesis of 17α-amino steroids has been developed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CC/C3CC49080G

Reference32 articles.

1. Role of a Disordered Steroid Metabolome in the Elucidation of Sterol and Steroid Biosynthesis

2. Enantioselective synthesis of steroids

3. D. J. Mack , M. L.Weinrich , E.Vitaku and J. T.Njardarson , Top 200 Brand Name Drugs by US Retail Sales in 2010, http://cbc.arizona.edu/njardarson/group/top-pharmaceuticals-poster

4. Steroid sulfatase inhibitors: Promising new tools for breast cancer therapy?

5. Steroid sulfatase inhibitors: A review covering the promising 2000–2010 decade

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