Copper(ii) complexes based on quinoline-derived Schiff-base ligands: synthesis, characterization, HSA/DNA binding ability, and anticancer activity-Reference-Cited by-同舟云学术

Copper(ii) complexes based on quinoline-derived Schiff-base ligands: synthesis, characterization, HSA/DNA binding ability, and anticancer activity

Published:2018 Issue:10 Volume:9 Page:1663-1672
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Hu Kun¹²³⁴⁵^ORCID,Liu Chensi¹²³⁴⁵,Li Jingui¹²³⁴⁵,Liang Fupei¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory Cultivation Base for Chemistry and Molecular Engineering of Medicinal Resources

2. School of Chemistry and Pharmacy

3. Guangxi Normal University

4. Guilin 541004

5. P. R. China

Abstract

Three Cu(ii) complexes (C1–C3) were designed and synthesized.C3, in particular, having a ligand derived from benzocaine, exhibited greater selectivity toward HeLa cells, arrested cell cycles, and promoted tumor cell apoptosis.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangxi Province

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00223A

Reference66 articles.

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