From in vitro to in cellulo: structure–activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

From in vitro to in cellulo: structure–activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa

Published:2014 Issue:32 Volume:12 Page:6094-6104
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Storz Michael P.¹²,Allegretta Giuseppe¹²,Kirsch Benjamin¹²,Empting Martin¹²,Hartmann Rolf W.¹²³⁴²

Affiliation:

1. Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)

2. 66123 Saarbrücken, Germany

3. Pharmaceutical and Medicinal Chemistry

4. Saarland University

Abstract

More than 60 derivatives of (2-nitrophenyl)methanol were synthesized and evaluated regarding their potency to inhibit PqsD. In vitro and in cellulo structure–activity relationships were derived.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00707G

Reference33 articles.

1. Quorum sensing as a population-density-dependent determinant of bacterial physiology

2. Quorum sensing in bacterial virulence

3. Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation

4. Quorum sensing inhibitors: a bargain of effects

5. Small Molecules for Interference with Cell-Cell-Communication Systems in Gram-Negative Bacteria

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