Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)

Published:2017 Issue:2 Volume:8 Page:465-470
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Schiedel M.¹²³⁴,Fallarero A.⁵⁶⁷⁸⁹,Luise C.¹⁰¹¹¹²⁴^ORCID,Sippl W.¹⁰¹¹¹²⁴,Vuorela P.⁵⁶⁷⁸⁹,Jung M.¹²³⁴^ORCID

Affiliation:

1. Institute of Pharmaceutical Sciences

2. University of Freiburg

3. 79104 Freiburg im Breisgau

4. Germany

5. Pharmaceutical Design and Discovery Research Group

6. Division of Pharmaceutical Biosciences

7. Faculty of Pharmacy

8. University of Helsinki (UHEL)

9. Helsinki

10. Institute of Pharmacy

11. Martin-Luther-University Halle-Wittenberg

12. 06120 Halle (Saale)

Abstract

Discovery of 8-hydroxy-2,7-naphthyridinium salts as a novel class of cholinesterase inhibitors inspired by the natural product chelerythrine.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C6MD00647G

Reference46 articles.

1. Comparison of butyrylcholinesterase and acetylcholinesterase

2. Widely Spread Butyrylcholinesterase Can Hydrolyze Acetylcholine in the Normal and Alzheimer Brain

3. Plasma butyrylcholinesterase regulates ghrelin to control aggression

4. Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors

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