Fragment-based covalent ligand discovery-Reference-Cited by-同舟云学术

Fragment-based covalent ligand discovery

Published:2021 Issue:2 Volume:2 Page:354-367
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Lu Wenchao¹²³⁴⁵^ORCID,Kostic Milka¹²³⁴^ORCID,Zhang Tinghu¹²³⁴⁵,Che Jianwei¹²³⁴⁵,Patricelli Matthew P.⁶⁷⁴,Jones Lyn H.⁸²³⁴^ORCID,Chouchani Edward T.¹²³⁴⁹,Gray Nathanael S.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Cancer Biology

2. Dana-Farber Cancer Institute

3. Boston

4. USA

5. Department of Biological Chemistry and Molecular Pharmacology

6. Vividion Therapeutics

7. La Jolla

8. Center for Protein Degradation

9. Department of Cell Biology

Abstract

Covalent fragment-based ligand discovery greatly facilitates the discovery of useful fragments for drug discovery and helps unveil chemical-tractable biological targets in native biological systems.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D0CB00222D

Reference121 articles.

1. Covalent Inhibition in Drug Discovery

2. Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation

3. Structure-based design of targeted covalent inhibitors

4. The resurgence of covalent drugs

5. Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket

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