New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling-Reference-Cited by-同舟云学术

New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling

Published:2017 Issue:1 Volume:9 Page:6-21
ISSN:1757-9694
Container-title:Integrative Biology
language:en
Short-container-title:Integr. Biol.

Author:

Sumit M.¹²³⁴⁵^ORCID,Takayama S.¹²³⁴⁵,Linderman J. J.⁶³⁴⁵⁷

Affiliation:

1. Biointerface Institute

2. North Campus Research Complex

3. University of Michigan

4. Ann Arbor

5. USA

6. Department of Biomedical Engineering

7. Department of Chemical Engineering

Abstract

A combined approach involving microfluidic pulsatile stimulation and mathematical modeling has led to deciphering of hidden/unknown temporal motifs in several mammalian signaling pathways and has provided mechanistic insights, including how these motifs process temporal signals and govern fate regulation.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

Link

http://pubs.rsc.org/en/content/articlepdf/2017/IB/C6IB00178E

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