Desymmetrization of pibrentasvir for efficient prodrug synthesis
Author:
Affiliation:
1. Drug Discovery Science & Technology
2. AbbVie, Inc.
3. North Chicago
4. USA
5. Process Research and Development
Abstract
Horeau principle statistical amplification and solubility-driven selectivities allow C2-desymmetrization of pibrentasvir without typically required internal functionalization or steric proximity effects.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02396A
Reference22 articles.
1. See www.mavyret.com
2. Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection
3. Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530)
4. Highlights of the Structure–Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530)
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