Dimerization-based control of cooperativity
Author:
Affiliation:
1. Icahn School of Medicine at Mount Sinai
2. Department of Pharmacology and Systems Therapeutics
3. New York, USA
Abstract
Kinetic modeling reveals that dimerization affinity can increase, eliminate, and even reverse cooperativity imposed by the canonical ligand-affinity mechanism highlighting a novel role for the ubiquitous signaling motif.
Funder
National Institute of General Medical Sciences
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
Molecular Biology,Biotechnology
Link
http://pubs.rsc.org/en/content/articlepdf/2014/MB/C4MB00022F
Reference45 articles.
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2. The Subunit Interfaces of Weakly Associated Homodimeric Proteins
3. The power of two: protein dimerization in biology
4. Dimer formation drives the activation of the cell death protease caspase 9
5. The E. coli bio operon: Transcriptional repression by an essential protein modification enzyme
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