Tailor-made gemcitabine prodrug nanoparticles from well-defined drug–polymer amphiphiles prepared by controlled living radical polymerization for cancer chemotherapy

Author:

Wang Weiwei1234,Li Chen1234,Zhang Ju1234,Dong Anjie564,Kong Deling1234

Affiliation:

1. Tianjin Key Laboratory of Biomaterial Research

2. Institute of Biomedical Engineering

3. Chinese Academy of Medical Science and Peking Union Medical College

4. Tianjin, China

5. School of Chemical Engineering and Technology

6. Tianjin University

Abstract

Novel prodrug nanoparticles with a tailorable high drug payload and in vivo anti-cancer activity assembled from well-defined gemcitabine–polymer conjugate amphiphiles prepared by RAFT polymerization are presented.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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