Affiliation:
1. School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi’an, 710061, China
2. Department of Pharmacy, Shenzhen Baoan Authentic TCM Therapy Hospital, Shenzhen, 518101, China
Abstract
Cancer is the second leading cause of human death after cardiovascular disease, and the
most used drugs in clinics are cytotoxic agents. However, these drugs have some inherent disadvantages,
such as the risk of toxicity, low selectivity, poor solubility, and so on. To overcome these
shortcomings, a variety of drug delivery strategies based on prodrugs have been developed. The application
of drug delivery systems can optimize ADME properties of cytotoxic agents and improve
their selectivity at the target, thereby greatly enhancing the anticancer effect in clinics. At present, it
has become mainstream in drug design. This review systematically summarized the studies of prodrug-
based drug delivery systems over the past five to ten years, according to four aspects, solubility,
controlled release, in situ concentration, and targeting.
Funder
Bao'an TCM Development Foundation
Xi’an Youth Talent Support Program
Fundamental Research Funds for the Central Universities
China Postdoctoral Science Foundation
Natural Science Basic Research Plan in Shaanxi Province of China
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献