AmAT19, an acetyltransferase from Astragalus membranaceus, catalyses specific 6α-OH acetylation for tetracyclic triterpenes and steroids-Reference-Cited by-同舟云学术

AmAT19, an acetyltransferase from Astragalus membranaceus, catalyses specific 6α-OH acetylation for tetracyclic triterpenes and steroids

Published:2021 Issue:33 Volume:19 Page:7186-7189
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Linlin¹^ORCID,Chen Kuan¹^ORCID,Wang Zilong¹^ORCID,Yi Yang¹,Zhang Meng¹,Hasan Aobulikasimu¹,Kuang Yi¹,Shaker Sharpkate¹,Yu Rong¹,Wang Haotian¹,Liu Haiyang²^ORCID,Ye Min¹^ORCID,Qiao Xue¹^ORCID

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China

2. State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

Abstract

AmAT19 could catalyze the specific 6α-OH acetylation of tetracyclic triterpenes and steroids to improve their inhibitory activity against 3CLpro of SARS-CoV-2.

Funder

Natural Science Foundation of Beijing Municipality

National Natural Science Foundation of China

State Key Laboratory of Phytochemistry and Plant Resources in West China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01106E

Reference27 articles.

1. Acetylated Triterpene Glycosides and Their Biological Activity from Holothuroidea Reported in the Past Six Decades