Microwave-assisted multicomponent synthesis of antiproliferative 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-ones

Author:

Patel Subham G.1ORCID,González-Bakker Aday2ORCID,Vala Ruturajsinh M.1ORCID,Patel Paras J.1ORCID,Puerta Adrián2ORCID,Malik Apoorva3ORCID,Sharma Rakesh K.3ORCID,Padrón José M.2ORCID,Patel Hitendra M.1ORCID

Affiliation:

1. Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India

2. BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, La Laguna E-38206, Spain

3. Sustainable Materials and Catalysts Research Laboratory (SMCRL), Department of Chemistry, Indian Institute of Technology, Jodhpur, India

Abstract

Herein, we demonstrate a simple, rapid and green synthesis of 2,4-dimethoxy-THPQs under microwave irradiation and their antiproliferative activity, in silico ADMET and drug-likeness studies were carried out.

Funder

Consejería de Educación, Universidades, Cultura y Deportes, Gobierno de Canarias

University Grants Commission

Agencia Canaria de Investigación, Innovación y Sociedad de la Información

European Social Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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