Label-free fibre optic Raman spectroscopy with bounded simplex-structured matrix factorization for the serial study of serum in amyotrophic lateral sclerosis-Reference-Cited by-同舟云学术

Label-free fibre optic Raman spectroscopy with bounded simplex-structured matrix factorization for the serial study of serum in amyotrophic lateral sclerosis

Published:2022 Issue:22 Volume:147 Page:5113-5120
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Alix James J. P.¹²^ORCID,Verber Nick S.¹²,Schooling Chlöe N.¹³,Kadirkamanathan Visakan³,Turner Martin R.⁴,Malaspina Andrea⁵,Day John C. C.⁶,Shaw Pamela J.¹²

Affiliation:

1. Sheffield Institute for Translational Neuroscience, University of Sheffield, UK

2. Neuroscience Institute, University of Sheffield, UK

3. Department of Automatic Control and Systems Engineering, University of Sheffield, UK

4. Nuffield Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

5. Blizard Institute, Queen Mary University of London, London, UK

6. Interface Analysis Centre, School of Physics, University of Bristol, UK

Abstract

We demonstrate the use of a fibre optic fluid cell to undertake spontaneous Raman spectroscopy. Advanced advanced matrix factorisation is then applied to identify key spectral patterns with potential improvements to clinical trial design.

Funder

National Institute for Health Research

Motor Neurone Disease Association

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/AN/D2AN00936F

Reference51 articles.

1. Amyotrophic lateral sclerosis

2. Imaging muscle as a potential biomarker of denervation in motor neuron disease