The metal dependence of single-metal mediated phosphodiester bond cleavage: a QM/MM study of a multifaceted human enzyme-Reference-Cited by-同舟云学术

The metal dependence of single-metal mediated phosphodiester bond cleavage: a QM/MM study of a multifaceted human enzyme

Published:2022 Issue:47 Volume:24 Page:29130-29140
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Kaur Rajwinder¹^ORCID,Aboelnga Mohamed M.¹^ORCID,Nikkel Dylan J.¹^ORCID,Wetmore Stacey D.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta, T1K 3M4, Canada

Abstract

QM/MM calculations rationalize the experimentally-observed metal dependence of a unique endonuclease that uses only a single metal to break the inherently stable phosphodiester bond in nucleic acids.

Funder

Natural Sciences and Engineering Research Council of Canada

University of Lethbridge

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D2CP04338F

Reference96 articles.

1. Phosphodiester models for cleavage of nucleic acids

2. Catalytic Metal Ions and Enzymatic Processing of DNA and RNA

3. Nucleases: diversity of structure, function and mechanism

4. One is enough: insights into the two-metal ion nuclease mechanism from global analysis and computational studies

5. Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Uncovering an effecient binary system as a chemosensor for visual and fluorescence detection of chromium (VI) in water samples;Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy;2024-11

2. Synthesis and characterization of novel Ru(III) complexes of 2‐aminopyrazine: Interaction with biomolecules, antineoplastic activity, and computational investigation;Applied Organometallic Chemistry;2024-03-12

3. Protonation-mediated DNA tile self-assembly with nuclease resistance characteristic for signal-amplified detection of microRNAs;Biosensors and Bioelectronics;2024-02

4. Is Metal Stabilization of the Leaving Group Required or Can Lysine Facilitate Phosphodiester Bond Cleavage in Nucleic Acids? A Computational Study of EndoV;Journal of Chemical Information and Modeling;2024-01-22

5. Luminescent and time-resolved determination of gemifloxacin mesylate in pharmaceutical formulations and spiked blood plasma samples using a lanthanide complex as a probe;Analytical Methods;2024