Design, synthesis, and biological evaluation of CXCR4 ligands-Reference-Cited by-同舟云学术

Design, synthesis, and biological evaluation of CXCR4 ligands

Published:2016 Issue:43 Volume:14 Page:10298-10311
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mona Christine E.¹²³⁴⁵,Besserer-Offroy Élie¹²³⁴⁵^ORCID,Cabana Jérôme¹²³⁴⁵,Leduc Richard¹²³⁴⁵,Lavigne Pierre⁶²³⁴⁵,Heveker Nikolaus⁷⁸⁹¹⁰⁴,Marsault Éric¹²³⁴⁵,Escher Emanuel¹²³⁴⁵

Affiliation:

1. Department of Pharmacology-Physiology

2. Université de Sherbrooke

3. Sherbrooke

4. Canada

5. Institut de Pharmacologie de Sherbrooke

6. Department of Biochemistry

7. Department of Biochemistry and Molecular Medicine

8. Centre de Recherche Hôpital Sainte-Justine

9. Université de Montréal

10. Montreal

Abstract

An amino functionalized analog of the CXCR4 ligand IT1t is of higher affinity and inverse agonistic potency on the CXCR4-CAM receptor N119S than IT1t.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01484D

Reference62 articles.

1. Chemokine receptors: multifaceted therapeutic targets

2. CXCR7, CXCR4 and CXCL12: An eccentric trio?

3. The Many Roles of Chemokines and Chemokine Receptors in Inflammation

4. Chemokine receptors and their role in inflammation and infectious diseases

5. Persistent Induction of the Chemokine Receptor CXCR4 by TGF-β1 on Synovial T Cells Contributes to Their Accumulation Within the Rheumatoid Synovium

Cited by 20 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans;Science Signaling;2024-03-19

2. Metal-free synthesis of 1,3-dichloro-1,5-diarylpentan-5-ones via cascade oxidative radical addition of styrenes with CHCl₃;Organic & Biomolecular Chemistry;2024

3. Stereoselective Synthesis of a Novel Series of Dispiro-oxindolopyrrolizidines Embodying Thiazolo[3,2-a]benzimidazole Motif: A Molecular Electron Density Theory Study of the Mechanism of the [3 + 2] Cycloaddition Reaction;Chemistry;2023-11-06

4. Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes;2023-11-02

5. Deep-Learning-Enhanced Diffusion Imaging Assay for Resolving Local-Density Effects on Membrane Receptors;Analytical Chemistry;2023-01-30