meta-Non-flat substituents: a novel molecular design to improve aqueous solubility in small molecule drug discovery-Reference-Cited by-同舟云学术

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meta-Non-flat substituents: a novel molecular design to improve aqueous solubility in small molecule drug discovery

Published:2021 Issue:2 Volume:19 Page:446-456
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ichikawa Yuki¹²³⁴^ORCID,Hiramatsu Michiaki¹²³⁴,Mita Yusuke¹²³⁴,Makishima Makoto⁵⁶⁴^ORCID,Matsumoto Yotaro⁷⁸⁹⁴^ORCID,Masumoto Yui⁷²³⁴,Muranaka Atsuya¹⁰¹¹¹²⁴^ORCID,Uchiyama Masanobu⁷²³⁴¹⁰^ORCID,Hashimoto Yuichi¹²³⁴,Ishikawa Minoru¹³⁸⁹⁴^ORCID

Affiliation:

1. Institute for Quantitative Biosciences

2. The University of Tokyo

3. Bunkyo-ku

4. Japan

5. Nihon University School of Medicine

6. Itabashi-ku

7. Graduate School of Pharmaceutical Sciences

8. Tohoku University

9. Sendai

10. Advanced Elements Chemistry Laboratory

11. RIKEN Cluster for Pioneering Research (CPR)

12. Wako-shi

13. Graduate School of Life Sciences

Abstract

We found a novel molecular design for improvement in the aqueous solubility of small molecule drugs.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Society for the Promotion of Science

Tokyo Biochemical Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB02083D

Reference48 articles.

1. Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space

2. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

3. Novel tactics for designing water-soluble molecules in drug discovery

4. Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

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