Universal endogenous antibody recruiting nanobodies capable of triggering immune effectors for targeted cancer immunotherapy

Author:

Hong Haofei12345ORCID,Li Chen12345,Gong Liang12345ORCID,Wang Jinfeng12345,Li Dan12345,Shi Jie12345,Zhou Zhifang12345ORCID,Huang Zhaohui67589,Wu Zhimeng12345ORCID

Affiliation:

1. Key Laboratory of Carbohydrate Chemistry & Biotechnology

2. Ministry of Education

3. School of Biotechnology

4. Jiangnan University

5. Wuxi

6. Wuxi Cancer Institute

7. Affiliated Hospital of Jiangnan University

8. China

9. Laboratory of Cancer Epigenetics

Abstract

Universal endogenous antibody recruiting nanobodies (UEAR Nbs), composed of IgGs binding domain and nanobody, could redirect endogenous IgGs onto target cell surfaces and evoke potent immune responses to eliminate cancer cells in vitro and in vivo.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

National Postdoctoral Program for Innovative Talents

China Postdoctoral Science Foundation

Higher Education Discipline Innovation Project

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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