Universal endogenous antibody recruiting nanobodies capable of triggering immune effectors for targeted cancer immunotherapy-Reference-Cited by-同舟云学术

Universal endogenous antibody recruiting nanobodies capable of triggering immune effectors for targeted cancer immunotherapy

Published:2021 Issue:12 Volume:12 Page:4623-4630
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hong Haofei¹²³⁴⁵^ORCID,Li Chen¹²³⁴⁵,Gong Liang¹²³⁴⁵^ORCID,Wang Jinfeng¹²³⁴⁵,Li Dan¹²³⁴⁵,Shi Jie¹²³⁴⁵,Zhou Zhifang¹²³⁴⁵^ORCID,Huang Zhaohui⁶⁷⁵⁸⁹,Wu Zhimeng¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Carbohydrate Chemistry & Biotechnology

2. Ministry of Education

3. School of Biotechnology

4. Jiangnan University

5. Wuxi

6. Wuxi Cancer Institute

7. Affiliated Hospital of Jiangnan University

8. China

9. Laboratory of Cancer Epigenetics

Abstract

Universal endogenous antibody recruiting nanobodies (UEAR Nbs), composed of IgGs binding domain and nanobody, could redirect endogenous IgGs onto target cell surfaces and evoke potent immune responses to eliminate cancer cells in vitro and in vivo.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

National Postdoctoral Program for Innovative Talents

China Postdoctoral Science Foundation

Higher Education Discipline Innovation Project

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC05332E