The effect of Fc region affinity of protein-based antibody-recruiting molecules on antibody-dependent cellular cytotoxicity-Reference-Cited by-同舟云学术

The effect of Fc region affinity of protein-based antibody-recruiting molecules on antibody-dependent cellular cytotoxicity

Published:2024 Issue:32 Volume:14 Page:22860-22866
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Tagawa Hiroshi¹,Saeki Riku¹,Yamamoto Chihaya¹,Tanito Kenta¹,Tanaka Chihiro²,Munekawa Shoki¹,Nii Teruki¹³,Kishimura Akihiro¹³⁴⁵,Murakami Hiroshi²⁶^ORCID,Mori Takeshi¹³⁴^ORCID,Katayama Yoshiki¹³⁴^ORCID

Affiliation:

1. Graduate School of Systems Life Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan

2. Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan

3. Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan

4. Center for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan

5. International Research Center for Molecular Systems, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan

6. Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan

Abstract

We report that novel protein-based Fc-binding antibody recruiting molecules (Fc-ARMs) with HER2-specific affibodies induce ADCC, but are less effective than conventional IgG-mediated ADCC and require further affinity improvement.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA03391D

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4. Chemical Control over Immune Recognition: A Class of Antibody-Recruiting Small Molecules That Target Prostate Cancer