Probing conformational hotspots for the recognition and intervention of protein complexes by lysine reactivity profiling
Author:
Affiliation:
1. CAS Key Laboratory of Separation Sciences for Analytical Chemistry
2. Dalian Institute of Chemical Physics
3. Chinese Academy of Sciences
4. Dalian 116023
5. China
6. Department of Chemistry
7. Zhejiang University
8. Hangzhou 310027
Abstract
A mass spectrometry-based two-step isotope labeling-lysine reactivity profiling strategy is developed to probe the molecular details of protein–protein interactions and evaluate the conformational interventions by small-molecule active compounds.
Funder
National Natural Science Foundation of China
Dalian Institute of Chemical Physics
Chinese Academy of Sciences
National Basic Research Program of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC05330A
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