Probing conformational hotspots for the recognition and intervention of protein complexes by lysine reactivity profiling-Reference-Cited by-同舟云学术

Probing conformational hotspots for the recognition and intervention of protein complexes by lysine reactivity profiling

Published:2021 Issue:4 Volume:12 Page:1451-1457
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Zheyi¹²³⁴⁵,Zhang Wenxiang¹²³⁴⁵,Sun Binwen¹²³⁴⁵,Ma Yaolu¹²³⁴⁵,He Min¹²³⁴⁵,Pan Yuanjiang⁶⁷⁸⁵^ORCID,Wang Fangjun¹²³⁴⁵^ORCID

Affiliation:

1. CAS Key Laboratory of Separation Sciences for Analytical Chemistry

2. Dalian Institute of Chemical Physics

3. Chinese Academy of Sciences

4. Dalian 116023

5. China

6. Department of Chemistry

7. Zhejiang University

8. Hangzhou 310027

Abstract

A mass spectrometry-based two-step isotope labeling-lysine reactivity profiling strategy is developed to probe the molecular details of protein–protein interactions and evaluate the conformational interventions by small-molecule active compounds.

Funder

National Natural Science Foundation of China

Dalian Institute of Chemical Physics

Chinese Academy of Sciences

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC05330A

Reference49 articles.

1. Predicting the Effects of Amino Acid Substitutions on Protein Function

2. Active site profiling reveals coupling between domains in SRC-family kinases

3. Predicting Deleterious Amino Acid Substitutions

4. Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions

5. Rapid mapping of protein functional epitopes by combinatorial alanine scanning

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent advances in application of computer-aided drug design in anti-COVID-19 Virials Drug Discovery;Biomedicine & Pharmacotherapy;2024-04

2. Protein painting for structural and binding site analysis via intracellular lysine reactivity profiling with o-phthalaldehyde;Chemical Science;2024

3. Unusual specific interaction of RBD with zeolite induces rapid neutralization of SARS-CoV-2;2023-11-07

4. Dracorhodin targeting CMPK2 attenuates inflammation: A novel approach to sepsis therapy;Clinical and Translational Medicine;2023-10

5. Integrated Analysis of Cross-Links and Dead-End Peptides for Enhanced Interpretation of Quantitative XL-MS;Journal of Proteome Research;2023-08-08