Mechanism of the feedback-inhibition resistance in aspartate kinase of Corynebacterium pekinense: from experiment to MD simulations-Reference-Cited by-同舟云学术

Mechanism of the feedback-inhibition resistance in aspartate kinase of Corynebacterium pekinense: from experiment to MD simulations

Published:2021 Issue:1 Volume:11 Page:30-38
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Liu Xiaoting¹²³⁴⁵^ORCID,Han Caijing¹²³⁴⁵,Fang Li¹²³⁴⁵,Fan Zhanqing¹²³⁴⁵,Wang Yanan¹²³⁴⁵,Gao Xin¹²³⁴⁵,Shi Junhua¹²³⁴⁵,Min Weihong¹²³⁴⁵^ORCID

Affiliation:

1. College of Food Science and Engineering

2. National Engineering Laboratory of Wheat and Corn Deep Processing

3. Jilin Agricultural University

4. Changchun 130118

5. People's Republic of China

Abstract

Corynebacterium pekinense AK was successfully modified and two mutants A380C and T379N/A380C with high enzyme activity were constructed. The mechanism of their feedback-inhibition resistance was thoroughly studied from experiment to MD simulations.

Funder

National Natural Science Foundation of China

Jilin Agricultural University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA09153G

Reference29 articles.

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2. Structural Insight into Concerted Inhibition of α2β2-Type Aspartate Kinase from Corynebacterium glutamicum

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5. The Structural Basis for Allosteric Inhibition of a Threonine-sensitive Aspartokinase

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