Photophysical and biological assessment of coumarin-6 loaded polymeric nanoparticles as a cancer imaging agent

Author:

Gregoriou Yiota12ORCID,Gregoriou Gregoria2,Manoli Andreas34,Papageorgis Paris34,Mc Larney Benedict5ORCID,Vangeli Despoina6,McColman Sarah7ORCID,Yilmaz Vural2ORCID,Hsu Hsiao-ting1,Skubal Magdalena5,Ogirala Anuja1,Athanasiou Evangelia38ORCID,Cramb David T.7ORCID,Dietis Nikolas6,Strati Katerina2ORCID,Itskos Grigorios34,Constantinou Andreas I.2,Andreou Chrysafis38ORCID

Affiliation:

1. Memorial Sloan Kettering Cancer Center, New York, NY, USA

2. Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus

3. Emphasis Research Centre, University of Cyprus, Nicosia, Cyprus

4. Department of Physics, University of Cyprus, Nicosia, Cyprus

5. Molecular Pharmacology Program, Memorial Sloan Kettering, New York, NY, USA

6. Medical School, University of Cyprus, Nicosia, Cyprus

7. Department of Chemistry and Biology, Toronto Metropolitan (Ryerson) University, Toronto, ON, Canada

8. Department of Electrical and Computer Engineering, University of Cyprus, Nicosia, Cyprus

Abstract

Coumarin-6 is used as a model hydrophobic drug to investigate delivery to tumors via polymeric micelles. Photophysical characterization, as well as in vitro and in vivo experiments showcase this platform for cancer diagnosis and imaging.

Funder

Research and Innovation Foundation

Center for Strategic Scientific Initiatives, National Cancer Institute

Fulbright Association

Natural Sciences and Engineering Research Council of Canada

Toronto Metropolitan University

Publisher

Royal Society of Chemistry (RSC)

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