Anticancer profile of coumarin 6-based Ir(<scp>iii</scp>) photocatalysts under normoxia and hypoxia by ROS generation and NADH oxidation-Reference-Cited by-同舟云学术

Anticancer profile of coumarin 6-based Ir(iii) photocatalysts under normoxia and hypoxia by ROS generation and NADH oxidation

Published:2024 Issue:17 Volume:11 Page:5435-5448
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Yadav Ashish Kumar¹^ORCID,Upadhyay Aarti²,Bera Arpan²,Kushwaha Rajesh¹^ORCID,Mandal Arif Ali¹,Acharjee Sagar¹,Kunwar Amit³⁴^ORCID,Banerjee Samya¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology (BHU) Varanasi, Uttar Pradesh 221005, India

2. Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, 560012, India

3. Radiation and Photochemistry Division, Bhabha Atomic Research Center, Anushaktinagar, Mumbai 400085, India

4. Homi Bhabha National Institute, Anushaktinagar, Mumbai – 400094, India

Abstract

Coumarin 6 appended Ir(iii) photocatalysts exhibited light activated anticancer effects against cancer cells via mitochondrial depolarization driven apoptosis by inducing type-I (NADH oxidation) and type-II (ROS generation) mechanisms.

Funder

Board of Research in Nuclear Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QI/D4QI01601G

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