Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery-Reference-Cited by-同舟云学术

Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery

Published:2017 Issue:91 Volume:53 Page:12345-12348
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Mayol-Llinàs Joan¹²³^ORCID,Farnaby William⁴⁵⁶⁷⁸,Nelson Adam¹²³⁹²^ORCID

Affiliation:

1. School of Chemistry

2. University of Leeds

3. UK

4. Takeda Cambridge

5. Unit 418

6. Cambridge Science Park

7. Milton Road

8. Cambridge

9. Astbury Centre for Structural Molecular Biology

Abstract

A modular synthetic approach was developed that yielded thirty diverse lead-like scaffolds suitable for CNS drug discovery.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC06078E

Reference28 articles.

1. Lead- and drug-like compounds: the rule-of-five revolution

2. CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure

3. CNS Physicochemical Property Space Shaped by a Diverse Set of Molecules with Experimentally Determined Exposure in the Mouse Brain

4. The Design of Leadlike Combinatorial Libraries

5. Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry

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