Molecular engineering of AIE-active boron clustoluminogens for enhanced boron neutron capture therapy-Reference-Cited by-同舟云学术

Molecular engineering of AIE-active boron clustoluminogens for enhanced boron neutron capture therapy

Published:2024 Issue:11 Volume:15 Page:4019-4030
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ma Wenli¹,Wang Yanyang²,Xue Yilin³,Wang Mengmeng¹,Lu Changsheng¹^ORCID,Guo Wanhua⁴,Liu Yuan-Hao⁵⁶⁷,Shu Diyun⁵⁶⁷,Shao Guoqiang³^ORCID,Xu Qinfeng⁸,Tu Deshuang¹,Yan Hong¹^ORCID

Affiliation:

1. State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

2. Department of Nuclear Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China

3. Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210033, China

4. Department of Nuclear Medicine, Nanjing Tongren Hospital, the Affiliated Hospital of Southeast University Medical School, Nanjing 210033, China

5. Neuboron Therapy System Ltd., Xiamen 361028, China

6. Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China

7. Neuboron Medtech Ltd., Nanjing 211112, China

8. Department of Nuclear Medicine, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China

Abstract

This study presents a new type of boron carrier for boron neutron capture therapy that integrates imaging, a lung cancer targeting drug and carborane, and showcases an impressive therapeutic efficacy against lung tumors both in vitro and in vivo.

Funder

Ministry of Science and Technology of the People's Republic of China

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC06222H

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